Real Madrid face a challenging period as Trent Alexander-Arnold has been ruled out for six to eight weeks after suffering a hamstring injury against Marseille. Ferland Mendy and Antonio Rudiger also remain sidelined, though there is a boost for Los Blancos with Endrick returning to the squad.
Defensive reshuffling will be required as Dean Huijsen serves a suspension following his red card against Real Sociedad. This could present an opportunity for Raul Asencio to slot into the heart of the defence.
In attack, Vinicius Junior is expected to reclaim his spot on the left wing, with Kylian Mbappe leading the line and Franco Mastantuono operating on the right. Rodrygo may therefore drop to the bench.
Midfield reinforcements are on hand, as Jude Bellingham and Eduardo Camavinga have both recovered from injury and are set to play a role, likely making appearances from the bench.
Espanyol, meanwhile, travel with injury concerns of their own. Brian Olivan is sidelined with a calf issue, and Jose Gragera faces a race against time to prove his fitness after a muscular problem.
The Catalan side will also be without Pere Milla, who is suspended following his red card against Mallorca — a significant blow given his three goals this season. Veteran forward Kike Garcia is tipped to step in, partnering Roberto Fernandez after scoring the late winner off the bench last time out.
